Tackling Critical Catalytic Residues in Helicobacter pylori l-Asparaginase

Bacterial asparaginases (amidohydrolases, EC 3.5.1.1) are important enzymes in cancer therapy, especially for Acute Lymphoblastic Leukemia. They are tetrameric enzymes able to catalyze the deamination of l-ASN and, to a variable extent, of l-GLN, on which leukemia cells are dependent for survival. I...

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Detalles Bibliográficos
Autores principales: Maggi, Maristella, Chiarelli, Laurent R, Valentini, Giovanna, Scotti, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496674/
https://www.ncbi.nlm.nih.gov/pubmed/25826146
http://dx.doi.org/10.3390/biom5020306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496674/
https://www.ncbi.nlm.nih.gov/pubmed/25826146
http://dx.doi.org/10.3390/biom5020306

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