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Sirtuins and Proteolytic Systems: Implications for Pathogenesis of Synucleinopathies

Insoluble and fibrillar forms of α-synuclein are the major components of Lewy bodies, a hallmark of several sporadic and inherited neurodegenerative diseases known as synucleinopathies. α-Synuclein is a natural unfolded and aggregation-prone protein that can be degraded by the ubiquitin-proteasomal...

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Detalles Bibliográficos
Autores principales: Sampaio-Marques, Belém, Ludovico, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496694/
https://www.ncbi.nlm.nih.gov/pubmed/25946078
http://dx.doi.org/10.3390/biom5020735