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Sirtuins and Proteolytic Systems: Implications for Pathogenesis of Synucleinopathies
Insoluble and fibrillar forms of α-synuclein are the major components of Lewy bodies, a hallmark of several sporadic and inherited neurodegenerative diseases known as synucleinopathies. α-Synuclein is a natural unfolded and aggregation-prone protein that can be degraded by the ubiquitin-proteasomal...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496694/ https://www.ncbi.nlm.nih.gov/pubmed/25946078 http://dx.doi.org/10.3390/biom5020735 |