Cargando…

RNA-Binding Proteins: Splicing Factors and Disease

Pre-mRNA splicing is mediated by interactions of the Core Spliceosome and an array of accessory RNA binding proteins with cis-sequence elements. Splicing is a major regulatory component in higher eukaryotes. Disruptions in splicing are a major contributor to human disease. One in three hereditary di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fredericks, Alger M., Cygan, Kamil J., Brown, Brian A., Fairbrother, William G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496701/ https://www.ncbi.nlm.nih.gov/pubmed/25985083 http://dx.doi.org/10.3390/biom5020893

Ejemplares similares

Mutational bias and the protein code shape the evolution of splicing enhancers
por: Rong, Stephen, et al.
Publicado: (2020)

RNA structure replaces the need for U2AF2 in splicing
por: Lin, Chien-Ling, et al.
Publicado: (2016)

Pathogenic variants that alter protein code often disrupt splicing
por: Soemedi, Rachel, et al.
Publicado: (2017)

Hereditary cancer genes are highly susceptible to splicing mutations
por: Rhine, Christy L., et al.
Publicado: (2018)

MMSplice: modular modeling improves the predictions of genetic variant effects on splicing
por: Cheng, Jun, et al.
Publicado: (2019)

Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness
por: Monaghan, Sean F., et al.
Publicado: (2018)

Deep RNA sequencing of intensive care unit patients with COVID-19
por: Fredericks, Alger M., et al.
Publicado: (2022)

An engineered RNA binding protein with improved splicing regulation
por: Hale, Melissa A, et al.
Publicado: (2018)

Splicing in a single neuron is coordinately controlled by RNA binding proteins and transcription factors
por: Thompson, Morgan, et al.
Publicado: (2019)

Pre-mRNA Splicing in Plants: In Vivo Functions of RNA-Binding Proteins Implicated in the Splicing Process
por: Meyer, Katja, et al.
Publicado: (2015)

SpliceAid-F: a database of human splicing factors and their RNA-binding sites
por: Giulietti, Matteo, et al.
Publicado: (2013)

Widespread intra-dependencies in the removal of introns from human transcripts
por: Kim, Seong Won, et al.
Publicado: (2017)

Hotspot exons are common targets of splicing perturbations
por: Glidden, David T., et al.
Publicado: (2021)

Identification and mechanistic basis of non-ACE2 blocking neutralizing antibodies from COVID-19 patients with deep RNA sequencing and molecular dynamics simulations
por: Fredericks, Alger M., et al.
Publicado: (2022)

Regulation of alternative splicing in Drosophila by 56 RNA binding proteins
por: Brooks, Angela N., et al.
Publicado: (2015)

Single Nucleotide Polymorphism–Based Validation of Exonic Splicing Enhancers
por: Fairbrother, William G, et al.
Publicado: (2004)

The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing
por: Zong, Feng-Yang, et al.
Publicado: (2014)

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
por: Johnson, Erik C. B., et al.
Publicado: (2018)

An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana
por: Streitner, Corinna, et al.
Publicado: (2012)

A KH-Domain RNA-Binding Protein Interacts with FIERY2/CTD Phosphatase-Like 1 and Splicing Factors and Is Important for Pre-mRNA Splicing in Arabidopsis
por: Chen, Tao, et al.
Publicado: (2013)

Non-cancer-related pathogenic germline variants and expression consequences in ten-thousand cancer genomes
por: Wang, Zishan, et al.
Publicado: (2021)

Disease modeling of core pre-mRNA splicing factor haploinsufficiency
por: Wood, Katherine A, et al.
Publicado: (2019)

The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x
por: Paronetto, Maria Paola, et al.
Publicado: (2007)

Position-dependent effects of RNA-binding proteins in the context of co-transcriptional splicing
por: Horn, Timur, et al.
Publicado: (2023)

Genome-Wide Identification of Alternatively Spliced mRNA Targets of Specific RNA-Binding Proteins
por: Robida, Mark D., et al.
Publicado: (2007)

Genome-wide regulation of KSHV RNA splicing by viral RNA-binding protein ORF57
por: Majerciak, Vladimir, et al.
Publicado: (2022)

Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1
por: Wang, Iren, et al.
Publicado: (2014)

ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing
por: Lee, Seungjae, et al.
Publicado: (2021)

The RNA binding protein Quaking represses splicing of the Fibronectin EDA exon and downregulates the interferon response
por: Liao, Kuo-Chieh, et al.
Publicado: (2021)

SpliceDisease database: linking RNA splicing and disease
por: Wang, Juan, et al.
Publicado: (2012)

Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp
por: Gotic, Ivana, et al.
Publicado: (2016)

Genome-wide analysis of dysregulated RNA-binding proteins and alternative splicing genes in keloid
por: Zhu, Zhen, et al.
Publicado: (2023)

The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals
por: Stagsted, Lotte Victoria Winther, et al.
Publicado: (2021)

Exonic splicing code and protein binding sites for calcium
por: Pengelly, Reuben J, et al.
Publicado: (2022)

Roles of Physicochemical and Structural Properties of RNA-Binding Proteins in Predicting the Activities of Trans-Acting Splicing Factors with Machine Learning
por: Zhu, Lin, et al.
Publicado: (2022)

Design and use of a back splicing junction probe for pulldown of circular RNA-binding proteins in cell lines
por: Li, Feiya, et al.
Publicado: (2022)

Molecular design of a splicing switch responsive to the RNA binding protein Tra2β
por: Grellscheid, Sushma Nagaraja, et al.
Publicado: (2011)

Involvement of the nuclear cap-binding protein complex in alternative splicing in Arabidopsis thaliana
por: Raczynska, Katarzyna Dorota, et al.
Publicado: (2010)

Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39
por: Campagne, Sébastien, et al.
Publicado: (2023)

The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex
por: Sena, Rebecca M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3u680n3lkg8ugt6ih6eh3iif2q