PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim

INTRODUCTION: Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase that is highly expressed in Human Epidermal Growth Factor 2(+) (Her2(+)) breast cancers. Overexpression of PTK6 enhances anchorage-independent survival, proliferation, and migration of breast cancer cells. We hypothesiz...

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Detalles Bibliográficos
Autores principales: Park, Sun Hee, Ito, Koichi, Olcott, William, Katsyv, Igor, Halstead-Nussloch, Gwyneth, Irie, Hanna Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496943/
https://www.ncbi.nlm.nih.gov/pubmed/26084280
http://dx.doi.org/10.1186/s13058-015-0594-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496943/
https://www.ncbi.nlm.nih.gov/pubmed/26084280
http://dx.doi.org/10.1186/s13058-015-0594-z

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