EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis

BACKGROUND: Type 4 phosphodiesterase (PDE4) inhibitors have been shown to stimulate bone formation in vivo and to stimulate osteoblastic differentiation in vitro. As one possible mechanism for the stimulation of bone formation is the recruitment of osteoprogenitor cells from the bone marrow, we have...

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Detalles Bibliográficos
Autores principales: Scutt, Andrew, Beier, Norbert, Fittschen, Claus
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC449707/
https://www.ncbi.nlm.nih.gov/pubmed/15219232
http://dx.doi.org/10.1186/1471-2210-4-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC449707/
https://www.ncbi.nlm.nih.gov/pubmed/15219232
http://dx.doi.org/10.1186/1471-2210-4-10

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