Efficient Asymmetric Synthesis of 1-Cyano-tetrahydroisoquinolines from Lipase Dual Activity and Opposite Enantioselectivities in α-Aminonitrile Resolution

Dual promiscuous racemization/amidation activities of lipases leading to efficient dynamic kinetic resolution protocols of racemic α-aminonitrile compounds are described. α-Amidonitrile products of high enantiomeric purity could be formed in high yields. Several lipases from different sources were s...

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Detalles Bibliográficos
Autores principales: Sakulsombat, Morakot, Vongvilai, Pornrapee, Ramström, Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497319/
https://www.ncbi.nlm.nih.gov/pubmed/25055970
http://dx.doi.org/10.1002/chem.201402615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497319/
https://www.ncbi.nlm.nih.gov/pubmed/25055970
http://dx.doi.org/10.1002/chem.201402615

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