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Efficient Asymmetric Synthesis of 1-Cyano-tetrahydroisoquinolines from Lipase Dual Activity and Opposite Enantioselectivities in α-Aminonitrile Resolution

Dual promiscuous racemization/amidation activities of lipases leading to efficient dynamic kinetic resolution protocols of racemic α-aminonitrile compounds are described. α-Amidonitrile products of high enantiomeric purity could be formed in high yields. Several lipases from different sources were s...

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Detalles Bibliográficos
Autores principales:	Sakulsombat, Morakot, Vongvilai, Pornrapee, Ramström, Olof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2014
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497319/ https://www.ncbi.nlm.nih.gov/pubmed/25055970 http://dx.doi.org/10.1002/chem.201402615

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