A randomized cross-over comparison of short-term exposure of once-daily extended release tacrolimus and twice-daily tacrolimus on renal function in healthy volunteers

Calcineurin inhibitor nephrotoxicity remains an issue for transplant recipients. The pharmacokinetic profile (PK) of the once-daily tacrolimus extended release (Tac-ER) includes equivalent exposure [AUC((0–24 h))] but lower C(max) versus twice-daily tacrolimus immediate release (Tac-IR). We hypothes...

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Detalles Bibliográficos
Autores principales: Zaltzman, Jeffrey S, Lai, Vesta, Schulz, Miklos Z, Moon, Kyung-Hee, Cherney, David Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2014
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497360/
https://www.ncbi.nlm.nih.gov/pubmed/25160518
http://dx.doi.org/10.1111/tri.12435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497360/
https://www.ncbi.nlm.nih.gov/pubmed/25160518
http://dx.doi.org/10.1111/tri.12435

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