Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions

The mammalian target of rapamycin (mTOR) correlates with cell survival under hypoxia and regulates hypoxia-inducible factor-1α (HIF-1α), a key protein in hypoxia-related events. However, the role of mTOR in radio-resistance has not been fully investigated. Therefore, the effect of mTOR on the radio-...

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Detalles Bibliográficos
Autores principales: Ushijima, Hiroki, Suzuki, Yoshiyuki, Oike, Takahiro, Komachi, Mayumi, Yoshimoto, Yuya, Ando, Ken, Okonogi, Noriyuki, Sato, Hiro, Noda, Shin-ei, Saito, Jun-ichi, Nakano, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497394/
https://www.ncbi.nlm.nih.gov/pubmed/25887043
http://dx.doi.org/10.1093/jrr/rrv021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497394/
https://www.ncbi.nlm.nih.gov/pubmed/25887043
http://dx.doi.org/10.1093/jrr/rrv021

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