Exploring Weak Ligand–Protein Interactions by Long-Lived NMR States: Improved Contrast in Fragment-Based Drug Screening**

Ligands that have an affinity for protein targets can be screened very effectively by exploiting favorable properties of long-lived states (LLS) in NMR spectroscopy. In this work, we describe the use of LLS for competitive binding experiments to measure accurate dissociation constants of fragments t...

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Detalles Bibliográficos
Autores principales: Buratto, Roberto, Mammoli, Daniele, Chiarparin, Elisabetta, Williams, Glyn, Bodenhausen, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497601/
https://www.ncbi.nlm.nih.gov/pubmed/25196717
http://dx.doi.org/10.1002/anie.201404921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497601/
https://www.ncbi.nlm.nih.gov/pubmed/25196717
http://dx.doi.org/10.1002/anie.201404921

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