Cargando…

Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme

To provide tight spatiotemporal signaling control, the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme typically nucleates a macromolecular complex or a “PKA signalosome.” Using the RIIβ holoenzyme as a prototype, we show how autophosphorylation/dephosphorylation of t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Ping, Knape, Matthias J., Ahuja, Lalima G., Keshwani, Malik M., King, Charles C., Sastri, Mira, Herberg, Friedrich W., Taylor, Susan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497662/ https://www.ncbi.nlm.nih.gov/pubmed/26158466 http://dx.doi.org/10.1371/journal.pbio.1002192

Ejemplares similares

PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice
por: Zhang, Jingliang, et al.
Publicado: (2021)

PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination
por: Isensee, Jörg, et al.
Publicado: (2018)

CaMKII autophosphorylation can occur between holoenzymes without subunit exchange
por: Lučić, Iva, et al.
Publicado: (2023)

Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma
por: Lu, Tsan-Wen, et al.
Publicado: (2020)

The Rate of NF-κB Nuclear Translocation Is Regulated by PKA and A Kinase Interacting Protein 1
por: King, Charles C., et al.
Publicado: (2011)

Molecular Basis for Ser/Thr Specificity in PKA Signaling
por: Knape, Matthias J., et al.
Publicado: (2020)

Dissociation between AKAP3 and PKA(RII) Promotes AKAP3 Degradation in Sperm Capacitation
por: Hillman, Pnina, et al.
Publicado: (2013)

RIIβ‐PKA in GABAergic Neurons of Dorsal Median Hypothalamus Governs White Adipose Browning
por: Wang, Bingwei, et al.
Publicado: (2022)

Isoform-specific targeting of PKA to multivesicular bodies
por: Day, Michele E., et al.
Publicado: (2011)

PKA Cα subunit mutation triggers caspase-dependent RIIβ subunit degradation via Ser(114) phosphorylation
por: Weigand, Isabel, et al.
Publicado: (2021)

Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases
por: Meharena, Hiruy S., et al.
Publicado: (2016)

Regulation of Cardiac PKA Signaling by cAMP and Oxidants
por: Cuello, Friederike, et al.
Publicado: (2021)

Molecular Features of Product Release for the PKA Catalytic Cycle
por: Bastidas, Adam C., et al.
Publicado: (2014)

Crystal Structures Reveal Hidden Domain Mechanics in Protein Kinase A (PKA)
por: Welsh, Colin L., et al.
Publicado: (2023)

Rational design of a PKA-based sensor for cGMP
por: Lorenz, Robin, et al.
Publicado: (2015)

The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA
por: Vetter, Maike M, et al.
Publicado: (2011)

The architecture of Tetrahymena telomerase holoenzyme
por: Jiang, Jiansen, et al.
Publicado: (2013)

Chemical tools selectively target components of the PKA system
por: Bertinetti, Daniela, et al.
Publicado: (2009)

BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle
por: Davis, Anthony J., et al.
Publicado: (2014)

The β Subunit of the Na(+)/K(+)-ATPase Follows the Conformational State of the Holoenzyme
por: Dempski, Robert E., et al.
Publicado: (2005)

Autophosphorylation and the Dynamics of the Activation of Lck
por: Kreusser, Lisa Maria, et al.
Publicado: (2021)

Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme
por: Cliffe, Rachel, et al.
Publicado: (2019)

Opposed Actions of PKA Isozymes (RI and RII) and PKC Isoforms (cPKCβI and nPKCε) in Neuromuscular Developmental Synapse Elimination
por: Garcia, Neus, et al.
Publicado: (2019)

Protein Kinase A in Human Retina: Differential Localization of Cβ, Cα, RIIα, and RIIβ in Photoreceptors Highlights Non-redundancy of Protein Kinase A Subunits
por: Roa, Jinae N., et al.
Publicado: (2021)

Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle
por: Wang, Yingjie, et al.
Publicado: (2019)

Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70
por: Ding, Cui-Ling, et al.
Publicado: (2015)

Organization of an Activator-Bound RNA Polymerase Holoenzyme
por: Bose, Daniel, et al.
Publicado: (2008)

Stepwise assembly of the human replicative polymerase holoenzyme
por: Hedglin, Mark, et al.
Publicado: (2013)

Structure of the processive human Pol δ holoenzyme
por: Lancey, Claudia, et al.
Publicado: (2020)

Role of the Holoenzyme PP1-SPN in the Dephosphorylation of the RB Family of Tumor Suppressors During Cell Cycle
por: Verdugo-Sivianes, Eva M., et al.
Publicado: (2021)

A simple in vitro method to measure autophosphorylation of protein kinases
por: Taylor, Isaiah, et al.
Publicado: (2013)

The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain
por: Schmidt, Sven H., et al.
Publicado: (2019)

The DNA polymerase III holoenzyme contains γ and is not a trimeric polymerase
por: Dohrmann, Paul R., et al.
Publicado: (2016)

Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides
por: Wang, Yuxiao, et al.
Publicado: (2014)

The CaMKII holoenzyme structure in activation-competent conformations
por: Myers, Janette B., et al.
Publicado: (2017)

Autophosphorylation of the Bacterial Tyrosine-Kinase CpsD Connects Capsule Synthesis with the Cell Cycle in Streptococcus pneumoniae
por: Nourikyan, Julien, et al.
Publicado: (2015)

Clinical Implications of TβRII Expression in Breast Cancer
por: Gao, Ningning, et al.
Publicado: (2015)

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors
por: Kufareva, Irina, et al.
Publicado: (2019)

Correction to Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides
por: Wang, Yuxiao, et al.
Publicado: (2014)

Transforming PKA into PKG – a structure-function approach to understand cyclic nucleotide selectivity
por: Lorenz, Robin, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_s9p6of7ot3mnlhc71c4tujhpgn