Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells

The rapid proliferation of myeloid leukemia cells is highly dependent on increased glucose metabolism. Through an unbiased metabolomics analysis of leukemia cells, we found that the glycogenic precursor UDP-D-glucose is pervasively upregulated, despite low glycogen levels. Targeting the rate-limitin...

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Detalles Bibliográficos
Autores principales: Bhanot, Haymanti, Reddy, Mamatha M., Nonami, Atsushi, Weisberg, Ellen L., Bonal, Dennis, Kirschmeier, Paul T., Salgia, Sabrina, Podar, Klaus, Galinsky, Ilene, Chowdary, Tirumala K., Neuberg, Donna, Tonon, Giovanni, Stone, Richard M., Asara, John, Griffin, James D., Sattler, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497855/
https://www.ncbi.nlm.nih.gov/pubmed/25703587
http://dx.doi.org/10.1038/leu.2015.46

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497855/
https://www.ncbi.nlm.nih.gov/pubmed/25703587
http://dx.doi.org/10.1038/leu.2015.46

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