Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most?

Human leukocyte antigen (HLA) genes are the most polymorphic genes in the human genome. Almost all polymorphic residues are located in the peptide-binding groove, resulting in different peptide-binding preferences. Whether a single amino acid change can alter the peptide-binding repertoire of an HLA...

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Detalles Bibliográficos
Autores principales: van Deutekom, Hanneke W. M., Keşmir, Can
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498290/
https://www.ncbi.nlm.nih.gov/pubmed/26040913
http://dx.doi.org/10.1007/s00251-015-0849-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498290/
https://www.ncbi.nlm.nih.gov/pubmed/26040913
http://dx.doi.org/10.1007/s00251-015-0849-y

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