Monoacylated Cellular Prion Proteins Reduce Amyloid-β-Induced Activation of Cytoplasmic Phospholipase A(2) and Synapse Damage

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) and the loss of synapses. Aggregation of the cellular prion protein (PrP(C)) by Aβ oligomers induced synapse damage in cultured neurons. PrP(C) is attached to membranes via a glyco...

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Detalles Bibliográficos
Autores principales: West, Ewan, Osborne, Craig, Nolan, William, Bate, Clive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498305/
https://www.ncbi.nlm.nih.gov/pubmed/26043272
http://dx.doi.org/10.3390/biology4020367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498305/
https://www.ncbi.nlm.nih.gov/pubmed/26043272
http://dx.doi.org/10.3390/biology4020367

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