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Monoacylated Cellular Prion Proteins Reduce Amyloid-β-Induced Activation of Cytoplasmic Phospholipase A(2) and Synapse Damage
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) and the loss of synapses. Aggregation of the cellular prion protein (PrP(C)) by Aβ oligomers induced synapse damage in cultured neurons. PrP(C) is attached to membranes via a glyco...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498305/ https://www.ncbi.nlm.nih.gov/pubmed/26043272 http://dx.doi.org/10.3390/biology4020367 |