Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays

Previous publications on stapled peptide inhibitors against Mdm2/Mdm4-p53 interactions have established that this new class of drugs have the potential to be easily optimised to attain high binding affinity and specificity, but the mechanisms controlling their cellular uptake and target engagement r...

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Detalles Bibliográficos
Autores principales: Xiong Tan, Ban, Brown, Christopher J., Ferrer, Fernando J., Yuen, Tsz Ying, Quah, Soo Tng, Chan, Boon Hong, Jansson, Anna E., Teo, Hsiang Ling, Nordlund, Pär, Lane, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498326/
https://www.ncbi.nlm.nih.gov/pubmed/26159518
http://dx.doi.org/10.1038/srep12116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498326/
https://www.ncbi.nlm.nih.gov/pubmed/26159518
http://dx.doi.org/10.1038/srep12116

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