Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice

Phosphodiesterase 4 (PDE4) has four isoforms (PDE4A-D) with at least 25 splice variants. PDE4 subtype nonselective inhibitors produce potent antidepressant-like and cognition-enhancing effects via increased intracellular cyclic AMP (cAMP) signaling in the brain. Our previous data have demonstrated t...

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Detalles Bibliográficos
Autores principales: Wang, Zhen-Zhen, Yang, Wei-Xing, Zhang, Yi, Zhao, Nan, Zhang, You-Zhi, Liu, Yan-Qin, Xu, Ying, Wilson, Steven P., O'Donnell, James M., Zhang, Han-Ting, Li, Yun-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498385/
https://www.ncbi.nlm.nih.gov/pubmed/26161529
http://dx.doi.org/10.1038/srep11332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498385/
https://www.ncbi.nlm.nih.gov/pubmed/26161529
http://dx.doi.org/10.1038/srep11332

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