The use of ion mobility mass spectrometry to probe modulation of the structure of p53 and of MDM2 by small molecule inhibitors

Developing drug-like molecules to inhibit the interactions formed by disordered proteins is desirable due to the high correlation of disorder with protein implicated in disease, but is challenging due in part to the lack of atomistically resolved and resolvable structures from conformationally dynam...

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Detalles Bibliográficos
Autores principales: Dickinson, Eleanor R., Jurneczko, Ewa, Nicholson, Judith, Hupp, Ted R., Zawacka-Pankau, Joanna, Selivanova, Galina, Barran, Perdita E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498441/
https://www.ncbi.nlm.nih.gov/pubmed/26217671
http://dx.doi.org/10.3389/fmolb.2015.00039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498441/
https://www.ncbi.nlm.nih.gov/pubmed/26217671
http://dx.doi.org/10.3389/fmolb.2015.00039

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