General Strategy to Introduce pH-Induced Allostery in DNA-Based Receptors to Achieve Controlled Release of Ligands

[Image: see text] Inspired by naturally occurring pH-regulated receptors, here we propose a rational approach to introduce pH-induced allostery into a wide range of DNA-based receptors. To demonstrate this we re-engineered two model DNA-based probes, a molecular beacon and a cocaine-binding aptamer,...

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Detalles Bibliográficos
Autores principales: Porchetta, Alessandro, Idili, Andrea, Vallée-Bélisle, Alexis, Ricci, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498449/
https://www.ncbi.nlm.nih.gov/pubmed/26053894
http://dx.doi.org/10.1021/acs.nanolett.5b00852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498449/
https://www.ncbi.nlm.nih.gov/pubmed/26053894
http://dx.doi.org/10.1021/acs.nanolett.5b00852

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