Asymmetric Synthesis of Substituted Thiolanes through Domino Thia-Michael–Henry Dynamic Covalent Systemic Resolution using Lipase Catalysis

Dynamic systems based on consecutive thia-Michael and Henry reactions were generated and transformed using lipase-catalyzed asymmetric transformation. Substituted thiolane structures with three contiguous stereocenters were resolved in the process in high yields and high enantiomeric excesses.

Detalles Bibliográficos
Autores principales: Zhang, Yan, Vongvilai, Pornrapee, Sakulsombat, Morakot, Fischer, Andreas, Ramström, Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498465/
https://www.ncbi.nlm.nih.gov/pubmed/26190961
http://dx.doi.org/10.1002/adsc.201301033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498465/
https://www.ncbi.nlm.nih.gov/pubmed/26190961
http://dx.doi.org/10.1002/adsc.201301033

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