Mutations Causing Complex Disease May under Certain Circumstances Be Protective in an Epidemiological Sense

Guided by the practice of classical epidemiology, research into the genetic basis of complex disease has usually taken for granted the dictum that causative mutations are invariably over-represented among clinically affected as compared to unaffected individuals. However, we show that this suppositi...

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Detalles Bibliográficos
Autores principales: Siegert, Sabine, Wolf, Andreas, Cooper, David N., Krawczak, Michael, Nothnagel, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498598/
https://www.ncbi.nlm.nih.gov/pubmed/26161957
http://dx.doi.org/10.1371/journal.pone.0132150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498598/
https://www.ncbi.nlm.nih.gov/pubmed/26161957
http://dx.doi.org/10.1371/journal.pone.0132150

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