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Mutations Causing Complex Disease May under Certain Circumstances Be Protective in an Epidemiological Sense
Guided by the practice of classical epidemiology, research into the genetic basis of complex disease has usually taken for granted the dictum that causative mutations are invariably over-represented among clinically affected as compared to unaffected individuals. However, we show that this suppositi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498598/ https://www.ncbi.nlm.nih.gov/pubmed/26161957 http://dx.doi.org/10.1371/journal.pone.0132150 |