From bacterial to human dihydrouridine synthase: automated structure determination

The reduction of uridine to dihydrouridine at specific positions in tRNA is catalysed by dihydrouridine synthase (Dus) enzymes. Increased expression of human dihydrouridine synthase 2 (hDus2) has been linked to pulmonary carcinogenesis, while its knockdown decreased cancer cell line viability, sugge...

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Detalles Bibliográficos
Autores principales: Whelan, Fiona, Jenkins, Huw T., Griffiths, Samuel C., Byrne, Robert T., Dodson, Eleanor J., Antson, Alfred A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498606/
https://www.ncbi.nlm.nih.gov/pubmed/26143927
http://dx.doi.org/10.1107/S1399004715009220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498606/
https://www.ncbi.nlm.nih.gov/pubmed/26143927
http://dx.doi.org/10.1107/S1399004715009220

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