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From bacterial to human dihydrouridine synthase: automated structure determination

The reduction of uridine to dihydrouridine at specific positions in tRNA is catalysed by dihydrouridine synthase (Dus) enzymes. Increased expression of human dihydrouridine synthase 2 (hDus2) has been linked to pulmonary carcinogenesis, while its knockdown decreased cancer cell line viability, sugge...

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Detalles Bibliográficos
Autores principales:	Whelan, Fiona, Jenkins, Huw T., Griffiths, Samuel C., Byrne, Robert T., Dodson, Eleanor J., Antson, Alfred A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2015
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498606/ https://www.ncbi.nlm.nih.gov/pubmed/26143927 http://dx.doi.org/10.1107/S1399004715009220

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