Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes

Somatic mutations in the isocitrate dehydrogenase (IDH)1/2 genes endow encoding proteins with neomorphic activity to produce the potential oncometabolite, 2-hydroxyglutarate (2-HG), which induces the hypermethylation of histones and DNA. The incidence of IDH1/2 mutations in cartilaginous tumors was...

Descripción completa

Detalles Bibliográficos
Autores principales: Jin, Yonghui, Elalaf, Hassan, Watanabe, Makoto, Tamaki, Sakura, Hineno, Sho, Matsunaga, Kazuhito, Woltjen, Knut, Kobayashi, Yukiko, Nagata, Sanae, Ikeya, Makoto, Kato, Tomohisa, Okamoto, Takeshi, Matsuda, Shuichi, Toguchida, Junya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498635/
https://www.ncbi.nlm.nih.gov/pubmed/26161668
http://dx.doi.org/10.1371/journal.pone.0131998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498635/
https://www.ncbi.nlm.nih.gov/pubmed/26161668
http://dx.doi.org/10.1371/journal.pone.0131998

Ejemplares similares