Functional Characterization of a Ketoreductase-Encoding Gene med-ORF12 Involved in the Formation of a Stereospecific Pyran Ring during the Biosynthesis of an Antitumor Antibiotic Medermycin

Medermycin, a polyketide antibiotic, possesses strong bioactivity against a variety of tumors through a novel mechanism and is structurally featured with a pyran ring containing two chiral centers (3S and 15R). By far the biosynthetic origin of such enantiomerical conformations still remains obscure...

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Detalles Bibliográficos
Autores principales: He, Qiang, Li, Le, Yang, Tingting, Li, Ruijuan, Li, Aiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498746/
https://www.ncbi.nlm.nih.gov/pubmed/26162081
http://dx.doi.org/10.1371/journal.pone.0132431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498746/
https://www.ncbi.nlm.nih.gov/pubmed/26162081
http://dx.doi.org/10.1371/journal.pone.0132431

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