CRISPR/Cas9n-Mediated Deletion of the Snail 1Gene (SNAI1) Reveals Its Role in Regulating Cell Morphology, Cell-Cell Interactions, and Gene Expression in Ovarian Cancer (RMG-1) Cells

Snail1 is a transcription factor that induces the epithelial to mesenchymal transition (EMT). During EMT, epithelial cells lose their junctions, reorganize their cytoskeletons, and reprogram gene expression. Although Snail1 is a prominent repressor of E-cadherin transcription, its precise roles in e...

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Detalles Bibliográficos
Autores principales: Haraguchi, Misako, Sato, Masahiro, Ozawa, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498756/
https://www.ncbi.nlm.nih.gov/pubmed/26161782
http://dx.doi.org/10.1371/journal.pone.0132260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498756/
https://www.ncbi.nlm.nih.gov/pubmed/26161782
http://dx.doi.org/10.1371/journal.pone.0132260

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