Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy

The efficacy of an antibody-drug conjugate (ADC) is dependent on the properties of its linker-payload which must remain stable while in systemic circulation but undergo efficient processing upon internalization into target cells. Here, we examine the stability of a non-cleavable Amino-PEG6-based lin...

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Detalles Bibliográficos
Autores principales: Dorywalska, Magdalena, Strop, Pavel, Melton-Witt, Jody A., Hasa-Moreno, Adela, Farias, Santiago E., Galindo Casas, Meritxell, Delaria, Kathy, Lui, Victor, Poulsen, Kris, Sutton, Janette, Bolton, Gary, Zhou, Dahui, Moine, Ludivine, Dushin, Russell, Tran, Thomas-Toan, Liu, Shu-Hui, Rickert, Mathias, Foletti, Davide, Shelton, David L., Pons, Jaume, Rajpal, Arvind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498778/
https://www.ncbi.nlm.nih.gov/pubmed/26161543
http://dx.doi.org/10.1371/journal.pone.0132282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498778/
https://www.ncbi.nlm.nih.gov/pubmed/26161543
http://dx.doi.org/10.1371/journal.pone.0132282

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