Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease

Herpesviruses encode a characteristic serine protease with a unique fold and an active site that comprises the unusual triad Ser-His-His. The protease is essential for viral replication and as such constitutes a promising drug target. In solution, a dynamic equilibrium exists between an inactive mon...

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Detalles Bibliográficos
Autores principales: Zühlsdorf, Martin, Werten, Sebastiaan, Klupp, Barbara G., Palm, Gottfried J., Mettenleiter, Thomas C., Hinrichs, Winfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498786/
https://www.ncbi.nlm.nih.gov/pubmed/26161660
http://dx.doi.org/10.1371/journal.ppat.1005045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498786/
https://www.ncbi.nlm.nih.gov/pubmed/26161660
http://dx.doi.org/10.1371/journal.ppat.1005045

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