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A novel mutation of SETBP1 in atypical chronic myeloid leukemia transformed from acute myelomonocytic leukemia

To investigate an oncogenic mutation of SETBP1 in the evolution from acute myelomonocytic leukemia (M4) to secondary aCML. Clinical data and molecular studies were analyzed of paired aCML and 'normal'DNA from a case with M4. We identified a mutation in SETBP1 (encoding a p.Asp868Ala altera...

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Detalles Bibliográficos
Autores principales: Hu, WangQiang, Wang, XiaoXia, Yang, RongRong, Xie, YaoSheng, Zhang, Zhuo, Lu, Hong, Wu, LianFeng, Lai, MeiMei, Yu, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498861/
https://www.ncbi.nlm.nih.gov/pubmed/26185647
http://dx.doi.org/10.1002/ccr3.243