A novel mutation of SETBP1 in atypical chronic myeloid leukemia transformed from acute myelomonocytic leukemia

To investigate an oncogenic mutation of SETBP1 in the evolution from acute myelomonocytic leukemia (M4) to secondary aCML. Clinical data and molecular studies were analyzed of paired aCML and 'normal'DNA from a case with M4. We identified a mutation in SETBP1 (encoding a p.Asp868Ala altera...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, WangQiang, Wang, XiaoXia, Yang, RongRong, Xie, YaoSheng, Zhang, Zhuo, Lu, Hong, Wu, LianFeng, Lai, MeiMei, Yu, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498861/
https://www.ncbi.nlm.nih.gov/pubmed/26185647
http://dx.doi.org/10.1002/ccr3.243
Descripción
Sumario:To investigate an oncogenic mutation of SETBP1 in the evolution from acute myelomonocytic leukemia (M4) to secondary aCML. Clinical data and molecular studies were analyzed of paired aCML and 'normal'DNA from a case with M4. We identified a mutation in SETBP1 (encoding a p.Asp868Ala alteration). The analysis of paired sample indicated that SETBP1 mutation was acquired during leukemic evolution.

Ejemplares similares