Mutagenesis Study Reveals the Rim of Catalytic Entry Site of HDAC4 and -5 as the Major Binding Surface of SMRT Corepressor

Histone deacetylases (HDACs) play a pivotal role in eukaryotic gene expression by modulating the levels of acetylation of chromatin and related transcription factors. In contrast to class I HDACs (HDAC1, -2, -3 and -8), the class IIa HDACs (HDAC4, -5, -7 and -9) harbor cryptic deacetylases activity...

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Detalles Bibliográficos
Autores principales: Kim, Gwang Sik, Jung, Ha-Eun, Kim, Jeong-Sun, Lee, Young Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498904/
https://www.ncbi.nlm.nih.gov/pubmed/26161557
http://dx.doi.org/10.1371/journal.pone.0132680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498904/
https://www.ncbi.nlm.nih.gov/pubmed/26161557
http://dx.doi.org/10.1371/journal.pone.0132680

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