Cargando…

A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

This study has used immunohistochemical examination of tissue obtained from Alzheimer’s disease (AD) brains and rat hippocampus injected with Aβ(1-42) peptide to determine effects of induced inflammatory reactivity on integrity of blood–brain barrier (BBB) and viability of neurons. Tissue from AD, b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ryu, Jae K, McLarnon, James G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2009
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498946/ https://www.ncbi.nlm.nih.gov/pubmed/18657226 http://dx.doi.org/10.1111/j.1582-4934.2008.00434.x

Ejemplares similares

A Leaky Blood–Brain Barrier to Fibrinogen Contributes to Oxidative Damage in Alzheimer’s Disease
por: McLarnon, James G.
Publicado: (2021)

Neural progenitor cells attenuate inflammatory reactivity and neuronal loss in an animal model of inflamed AD brain
por: Ryu, Jae K, et al.
Publicado: (2009)

VEGF receptor antagonist Cyclo-VEGI reduces inflammatory reactivity and vascular leakiness and is neuroprotective against acute excitotoxic striatal insult
por: Ryu, Jae K, et al.
Publicado: (2008)

Leaky Blood–Brain Barrier: A Double Whammy for the Brain
por: Wang, Yu
Publicado: (2020)

Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer’s disease
por: Ryu, Jae K, et al.
Publicado: (2015)

Leaky Gut, Leaky Brain?
por: Obrenovich, Mark E. M.
Publicado: (2018)

Mediators of cerebral hypoperfusion and blood‐brain barrier leakiness in Alzheimer’s disease, vascular dementia and mixed dementia
por: Tayler, Hannah, et al.
Publicado: (2021)

Correlated Inflammatory Responses and Neurodegeneration in Peptide-Injected Animal Models of Alzheimer's Disease
por: McLarnon, James G.
Publicado: (2014)

Comparison of Vascular Perturbations in an Aβ-Injected Animal Model and in AD Brain
por: Jantaratnotai, Nattinee, et al.
Publicado: (2011)

Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer’s disease
por: Miners, James, et al.
Publicado: (2023)

The impact of microglial activation on blood-brain barrier in brain diseases
por: da Fonseca, Anna Carolina Carvalho, et al.
Publicado: (2014)

Leaky barriers: leaky enough for fish to pass?
por: Müller, Stephanie, et al.
Publicado: (2021)

Microglial activation and blood–brain barrier leakage: chicken and egg?
por: Edison, Paul
Publicado: (2021)

Enhanced microglial pro‐inflammatory response to lipopolysaccharide correlates with brain infiltration and blood–brain barrier dysregulation in a mouse model of telomere shortening
por: Raj, Divya D. A., et al.
Publicado: (2015)

Inflaming the Brain with Iron
por: Urrutia, Pamela J., et al.
Publicado: (2021)

The blood-brain barrier in Alzheimer's disease
por: Zenaro, Elena, et al.
Publicado: (2017)

Microglial activation and blood–brain barrier permeability in cerebral small vessel disease
por: Walsh, Jessica, et al.
Publicado: (2021)

Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis
por: McLarnon, Michael, et al.
Publicado: (2021)

“Sports and Exercise Medicine Physician?”
por: McLarnon, Michael, et al.
Publicado: (2022)

T Cells Actively Infiltrate the White Matter of the Aging Monkey Brain in Relation to Increased Microglial Reactivity and Cognitive Decline
por: Batterman, Katelyn V., et al.
Publicado: (2021)

Blood–brain-barriers in aging and in Alzheimer’s disease
por: Marques, Fernanda, et al.
Publicado: (2013)

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
por: van Lengerich, Bettina, et al.
Publicado: (2023)

40.3 MATERNAL IMMUNE ACTIVATION AND CHRONIC HALOPERIDOL INTERACT TO INCREASE MICROGLIAL ACTIVATION IN VIVO: DO ANTIPSYCHOTICS INFLAME THE BRAIN?
por: Cotel, Marie-Caroline, et al.
Publicado: (2018)

Dyslipidemia and Blood-Brain Barrier Integrity in Alzheimer's Disease
por: Bowman, Gene L., et al.
Publicado: (2012)

Disruption of blood-brain barrier in Alzheimer disease pathogenesis
por: Kook, Sun-Young, et al.
Publicado: (2013)

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease
por: Yamazaki, Yu, et al.
Publicado: (2017)

Addressing Blood–Brain Barrier Impairment in Alzheimer’s Disease
por: Sharma, Chanchal, et al.
Publicado: (2022)

A call to action: the need for concussion assessment and diagnostic protocols for use in the different elite cycling disciplines, including paracyclists
por: McLarnon, Michael, et al.
Publicado: (2023)

Beyond the bowel – chaos caused by leaky barriers
por: Kattner, Aila Akosua
Publicado: (2023)

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation
por: Davalos, Dimitrios, et al.
Publicado: (2012)

Fibrinogen Chains Intrinsic to the Brain
por: Golanov, Eugene V., et al.
Publicado: (2019)

Phillyrin Prevents Neuroinflammation-Induced Blood–Brain Barrier Damage Following Traumatic Brain Injury via Altering Microglial Polarization
por: Jiang, Qian, et al.
Publicado: (2021)

In vivo two-photon microscopy protocol for imaging microglial responses and spine elimination at sites of fibrinogen deposition in mouse brain
por: Tognatta, Reshmi, et al.
Publicado: (2021)

The Blood-Brain Barrier and Microvascular Water Exchange in Alzheimer's Disease
por: Anderson, Valerie C., et al.
Publicado: (2011)

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?
por: Montagne, Axel, et al.
Publicado: (2017)

Treatment of Alzheimer’s Disease and Blood–Brain Barrier Drug Delivery
por: Pardridge, William M.
Publicado: (2020)

Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease
por: Lin, Zixuan, et al.
Publicado: (2021)

Discerning the Role of Blood Brain Barrier Dysfunction in Alzheimer’s Disease
por: Tao, Qing-Qing, et al.
Publicado: (2022)

Imaging blood–brain barrier disruption in neuroinflammation and Alzheimer’s disease
por: Lee, Rae-Ling, et al.
Publicado: (2023)

Brain ischemia and ischemic blood–brain barrier as etiological factors in sporadic Alzheimer’s disease
por: Pluta, Ryszard, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_hlhiid9p9fpi2iaa6spcl4j8e8