Cargando…

Small RNA-mediated DNA (cytosine-5) methyltransferase 1 inhibition leads to aberrant DNA methylation

Mammalian cells contain copious amounts of RNA including both coding and noncoding RNA (ncRNA). Generally the ncRNAs function to regulate gene expression at the transcriptional and post-transcriptional level. Among ncRNA, the long ncRNA and small ncRNA can affect histone modification, DNA methylatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Guoqiang, Estève, Pierre-Olivier, Chin, Hang Gyeong, Terragni, Jolyon, Dai, Nan, Corrêa, Ivan R., Pradhan, Sriharsa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499142/ https://www.ncbi.nlm.nih.gov/pubmed/25990724 http://dx.doi.org/10.1093/nar/gkv518

Ejemplares similares

Engineering the DNA cytosine-5 methyltransferase reaction for sequence-specific labeling of DNA
por: Lukinavičius, Gražvydas, et al.
Publicado: (2012)

Direct observation of cytosine flipping and covalent catalysis in a DNA methyltransferase
por: Gerasimaitė, Rūta, et al.
Publicado: (2011)

Automethylation of G9a and its implication in wider substrate specificity and HP1 binding
por: Chin, Hang Gyeong, et al.
Publicado: (2007)

Specific targeting of cytosine methylation to DNA sequences in vivo
por: Smith, Alexander E., et al.
Publicado: (2007)

The non-specific adenine DNA methyltransferase M.EcoGII
por: Murray, Iain A, et al.
Publicado: (2018)

Methyllysine Reader Plant Homeodomain (PHD) Finger Protein 20-like 1 (PHF20L1) Antagonizes DNA (Cytosine-5) Methyltransferase 1 (DNMT1) Proteasomal Degradation
por: Estève, Pierre-Olivier, et al.
Publicado: (2014)

A unique family of Mrr-like modification-dependent restriction endonucleases
por: Zheng, Yu, et al.
Publicado: (2010)

Novel non-specific DNA adenine methyltransferases
por: Drozdz, Marek, et al.
Publicado: (2012)

Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes
por: Li, Fuyang, et al.
Publicado: (2007)

RNA modulation of the human DNA methyltransferase 3A
por: Holz-Schietinger, Celeste, et al.
Publicado: (2012)

Residues of E. coli topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage
por: Narula, Gagandeep, et al.
Publicado: (2012)

The Caulobacter crescentus DNA-(adenine-N6)-methyltransferase CcrM methylates DNA in a distributive manner
por: Albu, Razvan F., et al.
Publicado: (2012)

High fidelity DNA strand-separation is the major specificity determinant in DNA methyltransferase CcrM’s catalytic mechanism
por: Konttinen, Olivia, et al.
Publicado: (2023)

The Helicobacter pylori HpyAXII restriction–modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components
por: Humbert, Olivier, et al.
Publicado: (2008)

Evolutionary transitions to new DNA methyltransferases through target site expansion and shrinkage
por: Rockah-Shmuel, Liat, et al.
Publicado: (2012)

Characterization of the dual role of Plasmodium falciparum DNA methyltransferase in regulating transcription and translation
por: Lucky, Amuza B, et al.
Publicado: (2023)

Cell cycle regulated DNA methyltransferase: fluorescent tracking of a DNA strand-separation mechanism and identification of the responsible protein motif
por: Konttinen, Olivia, et al.
Publicado: (2020)

Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells
por: Espada, Jesús, et al.
Publicado: (2007)

Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns
por: Emperle, Max, et al.
Publicado: (2019)

Structural and biochemical insight into the mechanism of dual CpG site binding and methylation by the DNMT3A DNA methyltransferase
por: Emperle, Max, et al.
Publicado: (2021)

Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6
por: Selmi, Tommaso, et al.
Publicado: (2020)

Type III restriction endonucleases are heterotrimeric: comprising one helicase–nuclease subunit and a dimeric methyltransferase that binds only one specific DNA
por: Butterer, Annika, et al.
Publicado: (2014)

Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N(6)-adenine DNA methyltransferases of Neisseria meningitidis
por: Seib, Kate L., et al.
Publicado: (2015)

Hyperthermophilic Aquifex aeolicus initiates primer synthesis on a limited set of trinucleotides comprised of cytosines and guanines
por: Larson, Marilynn A., et al.
Publicado: (2008)

KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli
por: Zhang-Akiyama, Qiu-Mei, et al.
Publicado: (2009)

2′-Deoxyriboguanylurea, the primary breakdown product of 5-aza-2′-deoxyribocytidine, is a mutagen, an epimutagen, an inhibitor of DNA methyltransferases and an inducer of 5-azacytidine-type fragile sites
por: Lamparska, Katarzyna, et al.
Publicado: (2012)

Comparative characterization of the PvuRts1I family of restriction enzymes and their application in mapping genomic 5-hydroxymethylcytosine
por: Wang, Hua, et al.
Publicado: (2011)

DNA-binding properties of T4 UvsY recombination mediator protein: polynucleotide wrapping promotes high-affinity binding to single-stranded DNA
por: Xu, Hang, et al.
Publicado: (2010)

Efficient DNA ligation in DNA–RNA hybrid helices by Chlorella virus DNA ligase
por: Lohman, Gregory J. S., et al.
Publicado: (2014)

Topoisomerase II minimizes DNA entanglements by proofreading DNA topology after DNA strand passage
por: Martínez-García, Belén, et al.
Publicado: (2014)

The DNA polymerase III holoenzyme contains γ and is not a trimeric polymerase
por: Dohrmann, Paul R., et al.
Publicado: (2016)

Promiscuous DNA synthesis by human DNA polymerase θ
por: Hogg, Matthew, et al.
Publicado: (2012)

Mechanism of DNA loading by the DNA repair helicase XPD
por: Constantinescu-Aruxandei, Diana, et al.
Publicado: (2016)

Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA–DNA pairing
por: Lin, Jiangguo, et al.
Publicado: (2016)

Low-fidelity DNA synthesis by human DNA polymerase theta
por: Arana, Mercedes E., et al.
Publicado: (2008)

Structural insight into negative DNA supercoiling by DNA gyrase, a bacterial type 2A DNA topoisomerase
por: Papillon, Julie, et al.
Publicado: (2013)

Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining
por: Kukshal, Vandna, et al.
Publicado: (2015)

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence
por: Gu, Jiafeng, et al.
Publicado: (2007)

Plasmid replication-associated single-strand-specific methyltransferases
por: Fomenkov, Alexey, et al.
Publicado: (2020)

Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences
por: Crespan, Emmanuele, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_q7qe095fhcq3r6eihd045sokfm