Identifying high-affinity aptamer ligands with defined cross-reactivity using high-throughput guided systematic evolution of ligands by exponential enrichment

Oligonucleotide aptamers represent a novel platform for creating ligands with desired specificity, and they offer many potentially significant advantages over monoclonal antibodies in terms of feasibility, cost, and clinical applicability. However, the isolation of high-affinity aptamer ligands from...

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Detalles Bibliográficos
Autores principales: Levay, Agata, Brenneman, Randall, Hoinka, Jan, Sant, David, Cardone, Marco, Trinchieri, Giorgio, Przytycka, Teresa M., Berezhnoy, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499151/
https://www.ncbi.nlm.nih.gov/pubmed/26007661
http://dx.doi.org/10.1093/nar/gkv534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499151/
https://www.ncbi.nlm.nih.gov/pubmed/26007661
http://dx.doi.org/10.1093/nar/gkv534

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