Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription

The AF4/FMR2 proteins AFF1 and AFF4 act as a scaffold to assemble the Super Elongation Complex (SEC) that strongly activates transcriptional elongation of HIV-1 and cellular genes. Although they can dimerize, it is unclear whether the dimers exist and function within a SEC in vivo. Furthermore, it i...

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Detalles Bibliográficos
Autores principales: Lu, Huasong, Li, Zichong, Zhang, Wei, Schulze-Gahmen, Ursula, Xue, Yuhua, Zhou, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499153/
https://www.ncbi.nlm.nih.gov/pubmed/26007649
http://dx.doi.org/10.1093/nar/gkv541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499153/
https://www.ncbi.nlm.nih.gov/pubmed/26007649
http://dx.doi.org/10.1093/nar/gkv541

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