Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor**

Cathepsin B (CtsB) is a lysosomal cysteine proteinase that is specifically translocated to the extracellular milieu during cancer progression. The development of a lipidated CtsB inhibitor incorporated into the envelope of a liposomal nanocarrier (LNC-NS-629) is described. Ex vivo and in vivo studie...

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Autores principales: Mikhaylov, G, Klimpel, D, Schaschke, N, Mikac, U, Vizovisek, M, Fonovic, M, Turk, V, Turk, Boris, Vasiljeva, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499245/
https://www.ncbi.nlm.nih.gov/pubmed/24975267
http://dx.doi.org/10.1002/anie.201402305
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author Mikhaylov, G
Klimpel, D
Schaschke, N
Mikac, U
Vizovisek, M
Fonovic, M
Turk, V
Turk, Boris
Vasiljeva, Olga
author_facet Mikhaylov, G
Klimpel, D
Schaschke, N
Mikac, U
Vizovisek, M
Fonovic, M
Turk, V
Turk, Boris
Vasiljeva, Olga
author_sort Mikhaylov, G
collection PubMed
description Cathepsin B (CtsB) is a lysosomal cysteine proteinase that is specifically translocated to the extracellular milieu during cancer progression. The development of a lipidated CtsB inhibitor incorporated into the envelope of a liposomal nanocarrier (LNC-NS-629) is described. Ex vivo and in vivo studies confirmed selective targeting and internalization of LNC-NS-629 by tumor and stromal cells, thus validating CtsB targeting as a highly promising approach to cancer diagnosis and treatment.
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spelling pubmed-44992452015-07-16 Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor** Mikhaylov, G Klimpel, D Schaschke, N Mikac, U Vizovisek, M Fonovic, M Turk, V Turk, Boris Vasiljeva, Olga Angew Chem Int Ed Engl Communications Cathepsin B (CtsB) is a lysosomal cysteine proteinase that is specifically translocated to the extracellular milieu during cancer progression. The development of a lipidated CtsB inhibitor incorporated into the envelope of a liposomal nanocarrier (LNC-NS-629) is described. Ex vivo and in vivo studies confirmed selective targeting and internalization of LNC-NS-629 by tumor and stromal cells, thus validating CtsB targeting as a highly promising approach to cancer diagnosis and treatment. WILEY-VCH Verlag 2014-09-15 2014-06-27 /pmc/articles/PMC4499245/ /pubmed/24975267 http://dx.doi.org/10.1002/anie.201402305 Text en © 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made
spellingShingle Communications
Mikhaylov, G
Klimpel, D
Schaschke, N
Mikac, U
Vizovisek, M
Fonovic, M
Turk, V
Turk, Boris
Vasiljeva, Olga
Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor**
title Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor**
title_full Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor**
title_fullStr Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor**
title_full_unstemmed Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor**
title_short Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor**
title_sort selective targeting of tumor and stromal cells by a nanocarrier system displaying lipidated cathepsin b inhibitor**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499245/
https://www.ncbi.nlm.nih.gov/pubmed/24975267
http://dx.doi.org/10.1002/anie.201402305
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