MicroRNA-143/-145 in Cardiovascular Diseases
MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovasc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499377/ https://www.ncbi.nlm.nih.gov/pubmed/26221598 http://dx.doi.org/10.1155/2015/531740 |
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author | Zhao, Wang Zhao, Shui-Ping Zhao, Yu-Hong |
author_facet | Zhao, Wang Zhao, Shui-Ping Zhao, Yu-Hong |
author_sort | Zhao, Wang |
collection | PubMed |
description | MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of vascular smooth muscle cells (VSMCs) and determines VSMC phenotypic switching. In this review, we summarize the recent progress in knowledge concerning the function of miR-143/-145 in the cardiovascular system and their role in cardiovascular diseases. We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145. |
format | Online Article Text |
id | pubmed-4499377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44993772015-07-28 MicroRNA-143/-145 in Cardiovascular Diseases Zhao, Wang Zhao, Shui-Ping Zhao, Yu-Hong Biomed Res Int Review Article MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of vascular smooth muscle cells (VSMCs) and determines VSMC phenotypic switching. In this review, we summarize the recent progress in knowledge concerning the function of miR-143/-145 in the cardiovascular system and their role in cardiovascular diseases. We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145. Hindawi Publishing Corporation 2015 2015-06-28 /pmc/articles/PMC4499377/ /pubmed/26221598 http://dx.doi.org/10.1155/2015/531740 Text en Copyright © 2015 Wang Zhao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhao, Wang Zhao, Shui-Ping Zhao, Yu-Hong MicroRNA-143/-145 in Cardiovascular Diseases |
title |
MicroRNA-143/-145 in Cardiovascular Diseases |
title_full |
MicroRNA-143/-145 in Cardiovascular Diseases |
title_fullStr |
MicroRNA-143/-145 in Cardiovascular Diseases |
title_full_unstemmed |
MicroRNA-143/-145 in Cardiovascular Diseases |
title_short |
MicroRNA-143/-145 in Cardiovascular Diseases |
title_sort | microrna-143/-145 in cardiovascular diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499377/ https://www.ncbi.nlm.nih.gov/pubmed/26221598 http://dx.doi.org/10.1155/2015/531740 |
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