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Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II)
[Image: see text] Further lead optimization on N-acyl-triazolopiperazine antagonists to the neurokinin-3 receptor (NK(3)R) based on the concurrent improvement in bioactivity and ligand lipophilic efficiency (LLE) is reported. Overall, compound 3 (LLE > 6) emerged as the most efficacious in castra...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2015
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499830/ https://www.ncbi.nlm.nih.gov/pubmed/26191358 http://dx.doi.org/10.1021/acsmedchemlett.5b00117 |