Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration

BACKGROUND: Mutations of acid sphingomyelinase (ASMase) cause Niemann–Pick diseases type A and B, which are fatal inherited lipid lysosomal storage diseases, characterized with visceral organ abnormalities and neurodegeneration. However, the effects of suppressing retinal ASMase expression are not u...

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Detalles Bibliográficos
Autores principales: Wu, Bill X., Fan, Jie, Boyer, Nicholas P., Jenkins, Russell W., Koutalos, Yiannis, Hannun, Yusuf A., Crosson, Craig E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500403/
https://www.ncbi.nlm.nih.gov/pubmed/26168297
http://dx.doi.org/10.1371/journal.pone.0133032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500403/
https://www.ncbi.nlm.nih.gov/pubmed/26168297
http://dx.doi.org/10.1371/journal.pone.0133032

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