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Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale
X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have de...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500945/ https://www.ncbi.nlm.nih.gov/pubmed/26169570 http://dx.doi.org/10.1038/srep12011 |
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author | Sung, Yongjin Segars, W. Paul Pan, Adam Ando, Masami Sheppard, Colin J. R. Gupta, Rajiv |
author_facet | Sung, Yongjin Segars, W. Paul Pan, Adam Ando, Masami Sheppard, Colin J. R. Gupta, Rajiv |
author_sort | Sung, Yongjin |
collection | PubMed |
description | X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have developed such a tool by combining a numerical anthropomorphic phantom defined with non-uniform rational B-splines (NURBS) and a wave optics-based simulator that can accurately capture the phase-contrast signal from a human-scaled numerical phantom. Using a synchrotron-based, high-performance XPCI system, we provide qualitative comparison between simulated and experimental images. Our tool can be used to simulate the performance of XPCI on various disease entities and compare proposed XPCI systems in an unbiased manner. |
format | Online Article Text |
id | pubmed-4500945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45009452015-07-17 Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale Sung, Yongjin Segars, W. Paul Pan, Adam Ando, Masami Sheppard, Colin J. R. Gupta, Rajiv Sci Rep Article X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have developed such a tool by combining a numerical anthropomorphic phantom defined with non-uniform rational B-splines (NURBS) and a wave optics-based simulator that can accurately capture the phase-contrast signal from a human-scaled numerical phantom. Using a synchrotron-based, high-performance XPCI system, we provide qualitative comparison between simulated and experimental images. Our tool can be used to simulate the performance of XPCI on various disease entities and compare proposed XPCI systems in an unbiased manner. Nature Publishing Group 2015-07-14 /pmc/articles/PMC4500945/ /pubmed/26169570 http://dx.doi.org/10.1038/srep12011 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Sung, Yongjin Segars, W. Paul Pan, Adam Ando, Masami Sheppard, Colin J. R. Gupta, Rajiv Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale |
title | Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale |
title_full | Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale |
title_fullStr | Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale |
title_full_unstemmed | Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale |
title_short | Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale |
title_sort | realistic wave-optics simulation of x-ray phase-contrast imaging at a human scale |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500945/ https://www.ncbi.nlm.nih.gov/pubmed/26169570 http://dx.doi.org/10.1038/srep12011 |
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