Artificial targeting of misfolded cytosolic proteins to endoplasmic reticulum as a mechanism for clearance

We report that misfolded cytosolic proteins can be cleared from mammalian cells by directing them to endoplasmic reticulum (ER). NAT1 R64W and Parkin R42P are naturally occurring misfolded variants of cytosolic enzymes that acetylate arylamines and ubiquitinate proteins, respectively. We demonstrate...

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Detalles Bibliográficos
Autores principales: Liu, Fen, Koepp, Deanna M., Walters, Kylie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501007/
https://www.ncbi.nlm.nih.gov/pubmed/26168740
http://dx.doi.org/10.1038/srep12088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501007/
https://www.ncbi.nlm.nih.gov/pubmed/26168740
http://dx.doi.org/10.1038/srep12088

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