Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution

BACKGROUND: Calicheamicins (CAL) are enedyine natural products with potent antibiotic and cytotoxic activity, used in anticancer therapy. The O-methyltransferase CalO6 is proposed to catalyze methylation of the hydroxyl moiety at the C2 position of the orsellinic acid group of CAL. RESULTS: Crystals...

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Detalles Bibliográficos
Autores principales: Tsodikov, Oleg V., Hou, Caixia, Walsh, Christopher T., Garneau-Tsodikova, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501126/
https://www.ncbi.nlm.nih.gov/pubmed/26170207
http://dx.doi.org/10.1186/s12900-015-0040-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501126/
https://www.ncbi.nlm.nih.gov/pubmed/26170207
http://dx.doi.org/10.1186/s12900-015-0040-6

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