AKT2-knockdown suppressed viability with enhanced apoptosis, and attenuated chemoresistance to temozolomide of human glioblastoma cells in vitro and in vivo

The AKT2 kinase (protein kinase Bβ) is overexpressed in high-grade gliomas. Upregulation of the AKT2 gene has been previously observed in glioblastoma patients suffering from chemotherapy failure and tumor progress. In this study, we aimed to evaluate the effect of AKT2 on viability and chemoresista...

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Detalles Bibliográficos
Autores principales: Cui, Yong, Lin, Jing, Zuo, Jianling, Zhang, Lei, Dong, Yan, Hu, Guohan, Luo, Chun, Chen, Juxiang, Lu, Yicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501163/
https://www.ncbi.nlm.nih.gov/pubmed/26185456
http://dx.doi.org/10.2147/OTT.S83795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501163/
https://www.ncbi.nlm.nih.gov/pubmed/26185456
http://dx.doi.org/10.2147/OTT.S83795

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