Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes

Alzheimer’s disease (AD) is characterized by the deposition of Beta-Amyloid (Aβ) peptides in the brain. Aβ peptides are generated by cleavage of the Amyloid Precursor Protein (APP) by the β − and γ − secretase enzymes. Although this process is tightly linked to the internalization of cell surface AP...

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Detalles Bibliográficos
Autores principales: Tang, Weihao, Tam, Joshua H.K., Seah, Claudia, Chiu, Justin, Tyrer, Andrea, Cregan, Sean P., Meakin, Susan O., Pasternak, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501290/
https://www.ncbi.nlm.nih.gov/pubmed/26170135
http://dx.doi.org/10.1186/s13041-015-0129-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501290/
https://www.ncbi.nlm.nih.gov/pubmed/26170135
http://dx.doi.org/10.1186/s13041-015-0129-7

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