Chemical Probes for the Functionalization of Polyketide Intermediates**

A library of functionalized chemical probes capable of reacting with ketosynthase-bound biosynthetic intermediates was prepared and utilized to explore in vivo polyketide diversification. Fermentation of ACP mutants of S. lasaliensis in the presence of the probes generated a range of unnatural polyk...

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Detalles Bibliográficos
Autores principales: Riva, Elena, Wilkening, Ina, Gazzola, Silvia, Li, W M Ariel, Smith, Luke, Leadlay, Peter F, Tosin, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501312/
https://www.ncbi.nlm.nih.gov/pubmed/25212788
http://dx.doi.org/10.1002/anie.201407448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501312/
https://www.ncbi.nlm.nih.gov/pubmed/25212788
http://dx.doi.org/10.1002/anie.201407448

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