Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Two parallel pathways produce cholesterol: the Bloch and Kandutsch-Russell pathways. Here we used stable isotope labeling and isotopomer analysis to trace sterol flux through the two pathways in mice. Surprisingly, no tissue used the canonical K–R pathway. Rather, a hybrid pathway was identified tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Mitsche, Matthew A, McDonald, Jeffrey G, Hobbs, Helen H, Cohen, Jonathan C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501332/
https://www.ncbi.nlm.nih.gov/pubmed/26114596
http://dx.doi.org/10.7554/eLife.07999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501332/
https://www.ncbi.nlm.nih.gov/pubmed/26114596
http://dx.doi.org/10.7554/eLife.07999

Ejemplares similares