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Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Two parallel pathways produce cholesterol: the Bloch and Kandutsch-Russell pathways. Here we used stable isotope labeling and isotopomer analysis to trace sterol flux through the two pathways in mice. Surprisingly, no tissue used the canonical K–R pathway. Rather, a hybrid pathway was identified tha...

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Detalles Bibliográficos
Autores principales:	Mitsche, Matthew A, McDonald, Jeffrey G, Hobbs, Helen H, Cohen, Jonathan C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501332/ https://www.ncbi.nlm.nih.gov/pubmed/26114596 http://dx.doi.org/10.7554/eLife.07999

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