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Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCF(Cdc4) recognition in Saccharomyces cerevisiae
To ensure genome integrity, DNA replication takes place only once per cell cycle and is tightly controlled by cyclin-dependent kinase (Cdk1). Cdc6p is part of the prereplicative complex, which is essential for DNA replication. Cdc6 is phosphorylated by cyclin-Cdk1 to promote its degradation after or...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501359/ https://www.ncbi.nlm.nih.gov/pubmed/25995377 http://dx.doi.org/10.1091/mbc.E14-07-1213 |